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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDK12
All Species:
18.18
Human Site:
S1130
Identified Species:
44.44
UniProt:
Q9NYV4
Number Species:
9
Phosphosite Substitution
Charge Score:
0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NYV4
NP_055898.1
1490
164155
S1130
L
Q
S
Q
T
D
L
S
I
P
Q
M
A
Q
L
Chimpanzee
Pan troglodytes
XP_001139939
1512
164915
N1106
L
Q
S
K
T
S
V
N
M
A
D
F
V
Q
V
Rhesus Macaque
Macaca mulatta
XP_001088594
1490
164086
S1130
L
Q
S
Q
T
D
L
S
I
P
Q
M
A
Q
L
Dog
Lupus familis
XP_548147
1490
164467
S1130
L
Q
S
Q
T
D
L
S
I
P
Q
M
A
Q
L
Cat
Felis silvestris
Mouse
Mus musculus
Q14AX6
1484
163663
S1126
L
Q
S
Q
T
D
L
S
I
P
Q
M
A
Q
L
Rat
Rattus norvegicus
Q3MJK5
1484
163772
S1126
L
Q
S
Q
T
D
L
S
I
P
Q
M
A
Q
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_687417
1286
141523
L977
S
Q
L
T
Q
D
Q
L
A
V
L
L
N
L
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_397595
1492
167042
D1167
E
K
R
I
T
A
A
D
A
L
K
S
A
W
L
Nematode Worm
Caenorhab. elegans
P46551
730
82410
I421
V
D
F
N
K
D
Q
I
C
S
L
F
K
Q
L
Sea Urchin
Strong. purpuratus
XP_789337
1264
139419
L955
E
N
L
N
M
Q
L
L
I
A
A
H
A
T
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
42.3
98.4
95.1
N.A.
91.1
91.7
N.A.
N.A.
N.A.
N.A.
39.1
N.A.
N.A.
36
27.6
35.7
Protein Similarity:
100
54.2
99.1
96.9
N.A.
94.7
95
N.A.
N.A.
N.A.
N.A.
50.4
N.A.
N.A.
51.7
36
49.5
P-Site Identity:
100
33.3
100
100
N.A.
100
100
N.A.
N.A.
N.A.
N.A.
20
N.A.
N.A.
20
20
20
P-Site Similarity:
100
66.6
100
100
N.A.
100
100
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
N.A.
33.3
26.6
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
10
10
0
20
20
10
0
70
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
10
0
0
0
0
0
0
% C
% Asp:
0
10
0
0
0
70
0
10
0
0
10
0
0
0
0
% D
% Glu:
20
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
10
0
0
0
0
0
0
0
0
20
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% H
% Ile:
0
0
0
10
0
0
0
10
60
0
0
0
0
0
0
% I
% Lys:
0
10
0
10
10
0
0
0
0
0
10
0
10
0
10
% K
% Leu:
60
0
20
0
0
0
60
20
0
10
20
10
0
10
80
% L
% Met:
0
0
0
0
10
0
0
0
10
0
0
50
0
0
0
% M
% Asn:
0
10
0
20
0
0
0
10
0
0
0
0
10
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
50
0
0
0
0
0
% P
% Gln:
0
70
0
50
10
10
20
0
0
0
50
0
0
70
0
% Q
% Arg:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
10
0
60
0
0
10
0
50
0
10
0
10
0
0
0
% S
% Thr:
0
0
0
10
70
0
0
0
0
0
0
0
0
10
0
% T
% Val:
10
0
0
0
0
0
10
0
0
10
0
0
10
0
10
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _